Valencia are without Manchester United loanee Andreas Pereira and Jeison Murillo.
Portuguese winger Goncalo Guedes hopes to play some part however.
Ousmane Dembele and Thomas Vermaelen are out for Barcelona, although the former has been back in training recently.
Valencia squad: Jaume, Neto, Montoya, Gabriel, Garay, Vezo, Gaya, Lato, Parejo, Maksimovic, Kondogbia, Coquelin, Carlos Soler, Guedes, Santi Mina, Rodrigo, Zaza, Vietto
Barcelona squad: Ter Stegen, Semedo, Piqué, Rakitic, Sergio Busquets, Iniesta, Luis Suárez, Messi, Cillessen, Coutinho, Paulinho, Paco Alcácer, Jordi Alba, Sergi Roberto, André Gomes, Aleix Vidal, Umtiti, Yerry Mina.